Rho-GTPases and downstream effector proteins involved in cell motility

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Presentation transcript:

Rho-GTPases and downstream effector proteins involved in cell motility. Rho-GTPases and downstream effector proteins involved in cell motility. RhoA acts via the effector proteins ROCK (RhoA effector protein Rho-associated kinase) and mDia to mediate actomyosin contraction and actin stabilisation. Rac1 acts via WAVE and PI-4-PK5 to mediate actin polymerisation and is involved in membrane protrusions. Cdc42 acts via PAR6 to mediate cell polarity and N-WASP to mediate actin polymerisation. Fraser R. Millar et al. Eur Respir Rev 2017;26:160069 ©2017 by European Respiratory Society