**This may be expedited depending on PRMC SOP Study targets cancer patients under active tx or with evidence of disease currently PRMC reviews** **This may be expedited depending on PRMC SOP Study targets cancer survivors Participants are at high risk of cancer* OR cancer is a study outcome Study excludes cancer patients/survivors Yes No PRMC does not review *Examples: -lung CT study of lung cancer detection in smokers -risk-reducing drug in women with BRCA1/2 mutations -large population study of diet patterns and cancer incidence Definition of “high risk”: incidence of cancer over the course of the study is expected to be higher than general population incidence