Glis: novel modulators of TCR signaling?

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Glis: novel modulators of TCR signaling? by Ursula Bommhardt Blood Volume 109(9):3618-3619 May 1, 2007 ©2007 by American Society of Hematology

Gli2ΔN2 influences Erk activation and thymocyte selection. Gli2ΔN2 influences Erk activation and thymocyte selection. Top panels: Gli2ΔN2 reduces negative selection in male HY-TCR Tg mice; middle panels: enhanced maturation of CD4+ T cells in female Shh+/− HY-TCR Tg mice; bottom histograms: Gli2ΔN2 Tg thymocytes show reduced activation of the MAPK Erk. See the complete figures in the article beginning on page3757. Ursula Bommhardt Blood 2007;109:3618-3619 ©2007 by American Society of Hematology