MENDEL AND THE GENE IDEA

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MENDEL AND THE GENE IDEA CHAPTER 14

WHAT YOU NEED TO KNOW: Terms associated with genetics problems: P, F1, F2, dominant, recessive, homozygous, heterozygous, phenotype, genotype. How to derive the proper gametes when working a genetics problem. The difference between an allele and a gene. How to read a pedigree.

Gregor Mendel Austrian monk Brought experimental and quantitative approach to genetics Bred pea plants to study inhertance Why peas? Control mating (self- vs. cross-pollination) Many varieties available Short generation time

P (parental) generation = true breeding plants F1 (first filial) generation = offspring F2 (second filial) generation = F1 offspring

Alleles: alternate versions of a gene

7 characters in pea plants Dominant vs. Recessive (expressed) or (hidden)

MENDEL’S PRINCIPLES Alternate version of genes (alleles) cause variations in inherited characteristics among offspring. For each character, every organism inherits one allele from each parent. If 2 alleles are different, the dominant allele will be fully expressed; the recessive allele will have no noticeable effect on offspring’s appearance. Law of Segregation: the 2 alleles for each character separate during gamete formation.

Law of Segregation

dominant (P), recessive (p) homozygous = 2 same alleles (PP or pp) heterozygous = 2 different alleles (Pp)

Phenotype: expressed physical traits Genotype: genetic make-up

Punnett Square Device for predicting offspring from a cross Genotypic Ratio: Phenotypic Ratio:

Testcross: determine if dominant trait is homozygous or heterozygous by crossing with recessive (pp)

Law of Independent Assortment: Each pair of alleles segregates (separates) independently during gamete formation Eg. color is separate from shape

Monohybrid cross: study 1 character eg. flower color Dihybrid cross: study 2 characters eg. flower color & seed shape

Dihybrid Cross

Extending Mendelian Genetics The relationship between genotype and phenotype is rarely simple Complete Dominance: heterozygote and homozygote for dominant allele are indistinguishable Eg. YY or Yy = yellow seed Incomplete Dominance: F1 hybrids have appearance that is between that of 2 parents Eg. red x white = pink flowers

Codominance: phenotype of both alleles is expressed Eg. red hair x white hairs = roan horses Multiple Alleles: gene has 2+ alleles Eg. human ABO blood groups Alleles = IA, IB, i IA,IB = Codominant

Blood Typing Phenotype (Blood Group) Genotype(s) Type A IAIA or IAi IBIB or IBi Type AB IAIB Type O ii

Blood Transfusions Blood transfusions must match blood type Mixing of foreign blood  clumping  death Rh factor: protein found on RBC’s (Rh+ = has protein, Rh- = no protein)

Blood Typing Problem: A man who is heterozygous with type A blood marries a woman who is homozygous with type B blood. What possible blood types might their children have?

Polygenic Inheritance: the effect of 2 or more genes acting upon a single phenotypic character (eg. skin color, height)

Nature and Nurture: both genetic and environmental factors influence phenotype Hydrangea flowers vary in shade and intensity of color depending on acidity and aluminum content of the soil.

Mendelian Inheritance in Humans Pedigree: diagram that shows the relationship between parents/offspring across 2+ generations Woman = Man = Trait expressed:

Pedigree Analysis

Genetic Disorders Autosomal Recessive Autosomal Dominant Cystic fibrosis (CF) Tay-Sachs disease Sickle-cell disease Phenylketonuria (PKU) Huntington’s disease (HD) Lethal dominant allele