Volume 123, Issue 2, Pages (August 2002)

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Volume 123, Issue 2, Pages 425-432 (August 2002) Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome Michael Camilleri, Elena Atanasova, Paula J. Carlson, Umraan Ahmad, H.Jae Kim, Blanca E. Viramontes, Sanna Mckinzie, Raul Urrutia Gastroenterology Volume 123, Issue 2, Pages 425-432 (August 2002) DOI: 10.1053/gast.2002.34780 Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 1 Polymorphisms in the gene for the serotonin transporter protein (SERT). (A) Physical map depicting long (L) and short (S) forms expected in genomic DNA of IBS patients, by using primers flanking the polymorphic region (see Materials and Methods). (B) A representative agarose gel stained with 1.5% ethidium bromide showing the 3 polymorphisms from patients who are heterozygous (LS), homozygous for the long form (L), and homozygous for the short form (S). Size markers (M) are indicated at left. (C) Genotypes identified by polymerase chain reaction were confirmed by direct sequencing, which showed the presence of the 44–base pair (bp) insertion. Gastroenterology 2002 123, 425-432DOI: (10.1053/gast.2002.34780) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 2 Colonic transit at 24 and 48 hours. Colonic transit at 24 and 48 hours in individual patients with (A) long polymorphism and (B) heterozygous polymorphism of the promoter region of SERT. Gastroenterology 2002 123, 425-432DOI: (10.1053/gast.2002.34780) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 3 Association of SERT polymorphism and colonic transit response to alosetron. Association of SERT polymorphism and colonic transit response to alosetron in patients with diarrhea-predominant irritable bowel syndrome. Note the difference in the change in colonic transit among groups, with the highest change in those with homozygous long polymorphism (P < 0.05 vs. heterozygous group). ANOVA, P = 0.075. *P = 0.039 vs. heterozygotes. Gastroenterology 2002 123, 425-432DOI: (10.1053/gast.2002.34780) Copyright © 2002 American Gastroenterological Association Terms and Conditions