Snail Enhances Glycolysis in the Epithelial-Mesenchymal Transition Process by Targeting FBP1 in Gastric Cancer Cell Physiol Biochem 2017;43:31–38 - DOI:10.1159/000480314.

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Snail Enhances Glycolysis in the Epithelial-Mesenchymal Transition Process by Targeting FBP1 in Gastric Cancer Cell Physiol Biochem 2017;43:31–38 - DOI:10.1159/000480314 Fig. 1. Snail promotes glycolysis in EMT process. (a), Successfully induced EMT by transfected Snail into AGS and MGC803 gastric cancer cell. (b), overexpression of Snail increased glucose uptake and lactate production via glycolysis in gastric cancer cells (*P<0.05). © 2017 The Author(s). Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

Snail Enhances Glycolysis in the Epithelial-Mesenchymal Transition Process by Targeting FBP1 in Gastric Cancer Cell Physiol Biochem 2017;43:31–38 - DOI:10.1159/000480314 Fig. 2. Statistical analysis of the correlation between Snail expression and the 18F-FDG PET/CT SUVmax. (a), Representative 18F-FDG PET/CT imaging of gastric cancer patients with low or high Snail expression (magnification scale bar, 20 µm). (b), Analysis of the SUVmax in Snail low and high groups (n = 32; P =0.022). © 2017 The Author(s). Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

Snail Enhances Glycolysis in the Epithelial-Mesenchymal Transition Process by Targeting FBP1 in Gastric Cancer Cell Physiol Biochem 2017;43:31–38 - DOI:10.1159/000480314 Fig. 3. Snail inhibited the transcriptional activation of FBP1. (a), Snail affected the expression of rate-limiting glycolytic enzymes determined by quantitative real-time RT-PCR analysis with the most significantly decreased FBP1. (b), Overexpression of Snail decreased FBP1 protein expression determined by Western blot analysis. (c), Snail decreased the FBP1 promoter activity in a dose dependent manner. © 2017 The Author(s). Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

Snail Enhances Glycolysis in the Epithelial-Mesenchymal Transition Process by Targeting FBP1 in Gastric Cancer Cell Physiol Biochem 2017;43:31–38 - DOI:10.1159/000480314 Fig. 4. Restoring FBP1 expression reversed the effect of glycolysis and EMT induced by Snail in gastric cancer cells. (a), Restoring FBP1 expression significantly decreased glucose utilization and lactate production. (b), Restoring FBP1 reversed the EMT process by Western blot analysis. © 2017 The Author(s). Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

Snail Enhances Glycolysis in the Epithelial-Mesenchymal Transition Process by Targeting FBP1 in Gastric Cancer Cell Physiol Biochem 2017;43:31–38 - DOI:10.1159/000480314 Fig. 5. Snail reversely correlated with FBP1 expression in gastric cancer. (a), Snail mRNA levels were inversely correlated with FBP1 mRNA levels in TCGA database (b), Representative images of Snail and FBP1 expression by IHC study in gastric tissues(200×). (c), A directly inverse correlation between Snail and FBP1 expression was found by IHC study in 69 gastric cancer patients’ specimens (P=0.015). © 2017 The Author(s). Published by S. Karger AG, Basel - CC BY-NC-ND 4.0