Treatment of Complicated Intra-abdominal Infections

What Makes a cIAI Complicated?

Case: 72-Year-Old Woman Presented to Emergency Department Severely Ill

Burden of cIAIs on the Healthcare System

Epidemiology of cIAIs Community-acquired vs Hospital-associated

Common Pathogens in Community-acquired cIAIs*

Common Pathogens in Community-acquired cIAIs (cont)

cIAIs Polymicrobial

cIAIs Initial Evaluation and Management

cIAIs Initial Evaluation and Management (cont)

cIAIs Initial Evaluation and Management (cont)

Empiric Antibiotic Therapy for cIAIs

STOP IT Appropriate Duration of Antibiotic Therapy?

STOP IT Benefit of Antibiotics Limited to First Few Days After Intervention

Empiric Antibiotic Therapy for cIAI Severity-based Selection*

ESBLs

Antibiotic Resistance

Novel Cephalosporins Coupled With a Beta-lactamase Inhibitor

RECLAIM-1 and RECLAIM-2 Phase 3 Trial Results of the Single-pooled Dataset

ASPECT-cIAI A Randomized, Double-blind, Phase 3 Trial of Hospitalized Patients With cIAI

Novel Cephalosporins Coupled With a Beta-lactamase Inhibitor Main Targets of Therapy

Treatment Failure

Abbreviations