Xiu-Zhen Zhang Reproductive BioMedicine Online

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Presentation transcript:

Modulation of embryonic stem cell fate and somatic cell reprogramming by small molecules Xiu-Zhen Zhang Reproductive BioMedicine Online Volume 21, Issue 1, Pages 26-36 (July 2010) DOI: 10.1016/j.rbmo.2010.03.021 Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 The schematic illustration of somatic cell reprogramming to induced pluripotent stem cells. Somatic cells are reprogrammed to induced pluripotent stem cells through viral or non-viral introduction of exogenous transcription factors or protein transduction. Small molecules can improve reprogramming efficiency and replace certain transcription factors through epigenetic modifications or signalling pathway regulation. 5-AzaC=5-azacytidine; EBNA1=Epstein–Barr nuclear antigen-1; IPS=induced pluripotent stem; SAHA=suberoylanilide hydroxamic acid; TSA=trichostatin A; VPA=valproic acid. Reproductive BioMedicine Online 2010 21, 26-36DOI: (10.1016/j.rbmo.2010.03.021) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions