Biomarkers in endometriosis: challenges and opportunities

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Presentation transcript:

Biomarkers in endometriosis: challenges and opportunities Soo Hyun Ahn, M.Sc., Vinay Singh, Ph.D., Chandrakant Tayade, D.V.M., Ph.D. Fertility and Sterility Volume 107, Issue 3, Pages 523-532 (March 2017) DOI: 10.1016/j.fertnstert.2017.01.009 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Cross-talk between the ectopic foci and eutopic endometrium. Chronic inflammation induced by the ectopic presence of endometrial fragments (damage-associated molecular patterns [DAMPs]) lead to potential epigenetic modification programming within the eutopic endometrium. Aberrant regulation of gene transcription and post-translational regulatory mechanisms through noncoding RNAs likely contribute to development of progesterone resistance and heightened response to estrogen, which are two key characteristics of the eutopic endometrium of women with endometriosis. In addition, chronic inflammation leads to hypersensitization of nerve fiber endings characterized by enhanced neuronal connectivity in areas of pain perception. lncRNA = long noncoding RNA; miRNA = microRNA. Fertility and Sterility 2017 107, 523-532DOI: (10.1016/j.fertnstert.2017.01.009) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions