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Nat. Rev. Cardiol. doi:10.1038/nrcardio.2017.108 Figure 3 Combined effects of cardiorespiratory fitness and body composition Figure 3 | Combined effects of cardiorespiratory fitness and body composition. The effects of BMI (part a), waist circumference (WC, part b), and percentage body fat (BF; part c) on all-cause mortality are presented. Hazard ratios (boxes) and 95% conﬁdence intervals are shown after adjusting for age, baseline examination year, physical activity (active or inactive), smoking status (current smoker or not), alcohol intake (>14 drinks/week or not), hypercholesterolaemia, hypertension, diabetes mellitus, and family history of cardiovascular disease. Reproduced from McAuley, P. A. et al. The obesity paradox, cardiorespiratory fitness, and coronary heart disease. Mayo Clin. Proc. 87, 443–451 (2012), with permission from Elsevier. Reproduced from McAuley, P. A. et al. The obesity paradox, cardiorespiratory fitness, and coronary heart disease. Mayo Clin. Proc. 87, 443–451 (2012), with permission from Elsevier Lavie, C. J. et al. (2017) Management of cardiovascular diseases in patients with obesity Nat. Rev. Cardiol. doi:10.1038/nrcardio.2017.108