Scheme of the design of the anti-lysozyme Goldbody.

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Scheme of the design of the anti-lysozyme Goldbody. Scheme of the design of the anti-lysozyme Goldbody. (A) Structure of cAb-Lys3 (green, with the CDR3 loop shown in magenta) in complex with HEWL (cyan) [Protein Data Bank (PDB) ID code 1MEL]. (B) Model of the anti-lysozyme Goldbody (with the grafted peptide loop shown in magenta) in complex with HEWL (cyan); for clarity, only one peptide is shown on the AuNP. (C) Structure of HEWL (cyan) in complex with its inhibitor Tri-NAG (shown as sticks) (PDB ID code 1HEW). (D) Sequences of the CDR3 fragment (100 to 112) of HEWL and the three designed peptides. Gui-Hua Yan et al. PNAS 2018;115:1:E34-E43 ©2018 by National Academy of Sciences