Volume 24, Issue 2, Pages (June 2017)

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Volume 24, Issue 2, Pages 91-98 (June 2017) High salt intake does not aggravate glucose dysregulation and dyslipidemia induced by estrogen-progestin oral contraceptive Oluwaseun A. Adeyanju, Taofeek O. Usman, Aboyeji L. Oyewole, Sikiru A. Biliaminu, Lawrence A. Olatunji Pathophysiology Volume 24, Issue 2, Pages 91-98 (June 2017) DOI: 10.1016/j.pathophys.2017.02.004 Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 1 Effect of treatment with estrogen-progestin oral contraceptive and high salt on post-load glucose response at (a) 30min (b) 60min and (c) 90min in female Wistar rats. 30minutes and 60min post-load glucose response was elevated in high salt treated rats. 90min hour post-load glucose response was elevated in low-dose OC, high-dose OC, high salt and high salt with high-dose OC-treated rats. Data are expressed as the mean±SEM of 6 rats in each group. Data were analyzed by one-way ANOVA followed by followed by Bonferroni post hoc test (*P<0.05 vs control). Pathophysiology 2017 24, 91-98DOI: (10.1016/j.pathophys.2017.02.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 2 Effect of treatment with estrogen-progestin oral contraceptive and high salt on (a) glucose tolerance and (b) insulin resistance, in female Wistar rats. Glucose tolerance was impaired in all the experimental groups. Treatment with high-dose OC and feeding on a high-salt diet with or without high-dose OC treatment resulted in insulin resistance. Data are expressed as the mean±SEM of 6 rats in each group. Data were analyzed by repeated measures of ANOVA followed by Bonferroni post hoc test (*P<0.05 vs control). Pathophysiology 2017 24, 91-98DOI: (10.1016/j.pathophys.2017.02.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 Effect of treatment with estrogen-progestin oral contraceptive and high salt on atherogenic indices (a&b) in female Wistar rats. Elevated TG/HDL-C ratio (a) was observed only in low and high doses of OC. TC/HDL-C ratio (b) was elevated in all the treated groups. Data are expressed as the mean±SEM of 6 rats in each group. Data were analyzed by one-way ANOVA followed by Bonferroni post hoc test (*P<0.05 vs control). Pathophysiology 2017 24, 91-98DOI: (10.1016/j.pathophys.2017.02.004) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 4 Effect of treatment with estrogen-progestin oral contraceptive and high salt on (a) plasma uric acid and (b) plasma C-reactive protein, in female Wistar rats. All the experimental groups had higher plasma uric acid level. Higher level of plasma C-reactive protein was also observed in all treatment groups except high salt- and high salt+high-dose OC-treated rats. Data are expressed as the mean±SEM of 6 rats in each group. Data were analyzed by one-way ANOVA followed by Bonferroni post hoc test (*P<0.05 vs control). Pathophysiology 2017 24, 91-98DOI: (10.1016/j.pathophys.2017.02.004) Copyright © 2017 Elsevier B.V. Terms and Conditions