The role of Fc gamma receptors polymorphisms in bullous pemphigoid

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Presentation transcript:

The role of Fc gamma receptors polymorphisms in bullous pemphigoid Antonio Guilabert, MD, Francisco Lozano, MD, Pilar Iranzo, MD, Marc Julià, MD, Belén Suárez-Casasús, Nemesio Moreno, MD, Josep Herrero-Gonzalez, MD, José Manuel Mascaró, MD Journal of the American Academy of Dermatology Volume 63, Issue 1, Pages 161-163 (July 2010) DOI: 10.1016/j.jaad.2009.09.010 Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Genotyping of Fc gamma receptors (FCGRs) polymorphisms. A, Direct sequencing of the FCGR2A gene showing nucleotide position 494 (amino acid position 131). This patient is heterozygous (HR; FCGR2A gene EMBL ID number: ENSG00000143226), B, Direct sequencing of the FCGR2B gene showing nucleotide position 775 (amino acid position 187) (arrow). This patient was found to be homozygous, resulting in the TT genotype (FCGR2B gene EMBL ID number: ENSG00000072694). C, Analysis of the amplified DNA product from six individuals using polymerase chain reaction with primers specific for FCGR3A-158V or FCGR3A-158F. One primer from the human growth hormone (HGH) gene that amplified a fragment of 480 base pairs was used as an internal positive control. Products were analyzed by electrophoresis on agarose gel and show possible combinations for the six patients: 1: VF; 2: VF; 3:FF; 4:VV; 5: VV; and 6: FF (FCGR3A gene EMBL ID number: ENSG00000203747). bp, Base pairs; HCG, human growth hormone; MWM, molecular weight marker. Journal of the American Academy of Dermatology 2010 63, 161-163DOI: (10.1016/j.jaad.2009.09.010) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions