The Angiotensin II Type 2 Receptor for Pain Control

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The Angiotensin II Type 2 Receptor for Pain Control A.H. Jan Danser, Praveen Anand Cell Volume 157, Issue 7, Pages 1504-1506 (June 2014) DOI: 10.1016/j.cell.2014.05.030 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Angiotensin II Formation and the Subsequent Activation of AT2 Receptors, Resulting in Either Hyperalgesia or Analgesia (A) The hyperalgesia pathway predominates in peripheral primary nociceptors and converges with the nerve growth factor-TRPV1 (transient receptor potential vanilloid subfamily member 1) pain pathway. (B) The mycolactone analgesia pathway may predominate in inflammatory cells and central nervous system neurons. PLA2, phospholipase A2; AA, arachidonic acid; COX-1, cyclooxygenase-1; PGE2, prostaglandin E2; TRAAK, TWIK-related, arachidonic acid-activated K+ channel. Cell 2014 157, 1504-1506DOI: (10.1016/j.cell.2014.05.030) Copyright © 2014 Elsevier Inc. Terms and Conditions