Tumor Microenvironment: No Effector T Cells without Dendritic Cells

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Presentation transcript:

Tumor Microenvironment: No Effector T Cells without Dendritic Cells Christina Pfirschke, Marie Siwicki, Hsin-Wei Liao, Mikael J. Pittet Cancer Cell Volume 31, Issue 5, Pages 614-615 (May 2017) DOI: 10.1016/j.ccell.2017.04.007 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 For Immune-Mediated Tumor Control, Dendritic Cells First, Effector T Cells to Follow Immune control of tumor growth relies on tumor-reactive effector T cells, with intratumoral Batf3-dependent CD103+ DCs as crucial instigators. These DCs must reach the tumor first—depicted here highest on the podium—as they generate chemokine signals (mainly CXCL9 and CXCL10) that result in effector T cell recruitment to the tumor and, ultimately, cancer control. Cancer Cell 2017 31, 614-615DOI: (10.1016/j.ccell.2017.04.007) Copyright © 2017 Elsevier Inc. Terms and Conditions