Abscopal Effect of Nivolumab in a Patient with Primary Lung Cancer

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Presentation transcript:

Abscopal Effect of Nivolumab in a Patient with Primary Lung Cancer Tetsuya Komatsu, MD, Katsumasa Nakamura, MD Journal of Thoracic Oncology Volume 12, Issue 9, Pages e143-e144 (September 2017) DOI: 10.1016/j.jtho.2017.05.004 Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 (A) Contrast-enhanced computed tomography (CECT) image showing liver metastasis in the right posterior segment at the first detection. (B) Chest computed tomography (CT) image showing intrapulmonary metastasis in the right lower lobe at the first detection. (C) Noncontrast chest CT image before nivolumab treatment showing the tumor growth compared with before chemotherapy. (D) Chest CT image before nivolumab treatment showing the increase in size of the intrapulmonary metastasis versus before chemotherapy. (E) CECT image after nivolumab treatment showing further tumor growth versus before treatment. (F) Chest CT image after nivolumab treatment showing a slight increase in size versus before treatment. (G) CECT image at 3 weeks after radiotherapy completion showing the substantial tumor shrinkage. (H) Chest CT image at 3 weeks after completion of radiotherapy showing the marked shrinkage of intrapulmonary metastasis (which was not irradiated), demonstrating the abscopal effect. Journal of Thoracic Oncology 2017 12, e143-e144DOI: (10.1016/j.jtho.2017.05.004) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 The treatment plan isodose distribution for liver metastasis. Red indicates planning target volume, and green indicates liver. Journal of Thoracic Oncology 2017 12, e143-e144DOI: (10.1016/j.jtho.2017.05.004) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions