Cystic fibrosis-related bone disease in children: Examination of peripheral quantitative computed tomography (pQCT) data Denise S.K. Brookes, Julie N.

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Cystic fibrosis-related bone disease in children: Examination of peripheral quantitative computed tomography (pQCT) data Denise S.K. Brookes, Julie N. Briody, Craig F. Munns, Peter S.W. Davies, Rebecca J. Hill Journal of Cystic Fibrosis Volume 14, Issue 5, Pages 668-677 (September 2015) DOI: 10.1016/j.jcf.2015.04.005 Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 vBMD, bone CSA and BSIc at the 4% tibia site: (A) pre-pubertal males and females, CF (blue or pink) vs Controls; (B) pubertal males and females, CF (blue or pink) vs Controls, mean (SD). Journal of Cystic Fibrosis 2015 14, 668-677DOI: (10.1016/j.jcf.2015.04.005) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 vBMD, CSA and SSI at 66% tibia site: (A) pre-pubertal males and females, CF (blue or pink) vs Controls; (B) pubertal males and females, CF (blue or pink) vs Controls, mean (SD). Journal of Cystic Fibrosis 2015 14, 668-677DOI: (10.1016/j.jcf.2015.04.005) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 Relationships of: (A) tibia SSI plotted against age, regression equation: CF SSI=125.94×age−103.5 vs. Control SSI=183.86×age−594.57; ‘intercepts’, p=0.00; ‘slopes’, p=0.03 (B) radius SSI plotted against age, regression equations: CF SSI=15.51×age−15.3 vs. Control radius SSI=21.65×age−62.42, ‘intercepts’, p=0.01; (C) tibia BSIc plotted against age, ‘slopes’, p=0.00; and (D) radius BSIc plotted against age, ‘intercepts’, p=0.05. Journal of Cystic Fibrosis 2015 14, 668-677DOI: (10.1016/j.jcf.2015.04.005) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 4 Relationships of: (A) size adjusted tibia mCSA plotted against age, regression equations: CF mCSA/length1.9=0.08×age+4.6 vs. Control mCSA/length1.9=0.2×age+3.6; and (B) radius BSIc plotted against size adjusted mCSA, regression equations: CF BSIc=1388.26×mCSA/length2.3+300.19 vs. Controls BSIc=3023.03×mCSA/length2.3−1970.01. Journal of Cystic Fibrosis 2015 14, 668-677DOI: (10.1016/j.jcf.2015.04.005) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions