Volume 60, Issue 6, Pages 1226-1234 (December 2011) SRD5A Polymorphisms and Biochemical Failure After Radical Prostatectomy  Etienne Audet-Walsh, Judith Bellemare, Geneviève Nadeau, Louis Lacombe, Yves Fradet, Vincent Fradet, Shu-Pin Huang, Bo-Ying Bao, Pierre Douville, Hugo Girard, Chantal Guillemette, Eric Lévesque  European Urology  Volume 60, Issue 6, Pages 1226-1234 (December 2011) DOI: 10.1016/j.eururo.2011.06.020 Copyright © 2011 European Association of Urology Terms and Conditions

Fig. 1 Risk of recurrence associated with known (A) clinical and pathologic prognostic variables and (B) germ-line variations in SRD5A genes for white men with localised prostate cancer (n=526). Boxes represent hazard ratios (HRs) and their 95% confidence intervals in multivariate analyses as described in Table 2. Prostate-specific antigen (PSA) categories are in nanograms per milliliter. Reference categories (HR: 1.00) for clinicopathologic characteristics are PSA at diagnosis ≤10 ng/ml, pathologic Gleason score ≤6, and pathologic stage ≤pT2c. Reference categories (HR: 1.00) for genotypes are individuals with a major allele (homozygous or heterozygous, as described in Table 2). Genetic linkage between haplotype-tagging single nucleotide polymorphisms tested for each SRD5A gene is represented in the triangles on the left in panel B. NS=nonsignificant. European Urology 2011 60, 1226-1234DOI: (10.1016/j.eururo.2011.06.020) Copyright © 2011 European Association of Urology Terms and Conditions

Fig. 2 Kaplan-Meier curves of biochemical recurrence for (A) SRD5A1 and (B) SRD5A2 in cohort of localised cases of white men with prostate cancer (n=526). Log-rank (LR) p values are shown in each frame. European Urology 2011 60, 1226-1234DOI: (10.1016/j.eururo.2011.06.020) Copyright © 2011 European Association of Urology Terms and Conditions

Fig. 3 Protective effects of single nucleotide polymorphisms in SRD5A genes in whites (rs12470143 and rs518673; n=526) and Asians (rs12470143; n=320) with localised prostate cancer. Hazard ratios (HRs) and their 95% confidence intervals (CIs) in multivariate analyses are indicated under each biochemical recurrence (BCR)–free curve. The BCR rate for every group is also indicated below each frame (% BCR). European Urology 2011 60, 1226-1234DOI: (10.1016/j.eururo.2011.06.020) Copyright © 2011 European Association of Urology Terms and Conditions

Fig. 4 Haplotype-tagging single nucleotide polymorphisms in SRD5A genes associated with an increased risk of biochemical recurrence after radical prostatectomy in whites (n=526) and in Asians with localised prostate cancer (n=320). Boxes represent hazard ratios (HRs) and their 95% confidence intervals (CIs) in multivariate analyses for rs676033, rs4952197, rs2208532 and rs523349. Reference categories (HR: 1.00) for genotypes are individuals with a major allele (homozygous and heterozygous); in Asians, rs2208532 tags for rs523349. European Urology 2011 60, 1226-1234DOI: (10.1016/j.eururo.2011.06.020) Copyright © 2011 European Association of Urology Terms and Conditions