Mazaher Gholipourmalekabadi, Susan Zhao, Benjamin S

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Oxygen-Generating Biomaterials: A New, Viable Paradigm for Tissue Engineering? Mazaher Gholipourmalekabadi, Susan Zhao, Benjamin S. Harrison, Masoud Mozafari, Alexander M. Seifalian Trends in Biotechnology Volume 34, Issue 12, Pages 1010-1021 (December 2016) DOI: 10.1016/j.tibtech.2016.05.012 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 The World's First Synthetic Trachea Made of Nanocomposite 3D Scaffold and Autologous Stem Cells, Implanted in a 36-year-old Patient in June 2011 [5]. Trends in Biotechnology 2016 34, 1010-1021DOI: (10.1016/j.tibtech.2016.05.012) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 2 (A) H2O2-PLGA-catalase/Alginate [20]. (B) H2O2 was fixed to PVP, encapsulated in PLGA, and surrounded with catalase-containing hydrogel [17]. Abbreviations: H2O2, hydrogen peroxide; PLGA, poly(d,l-lactide-co-glycolide); PVP, poly(vinyl pyrrolidone). Trends in Biotechnology 2016 34, 1010-1021DOI: (10.1016/j.tibtech.2016.05.012) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure I Tissue Engineering Strategies for Organ Development. (First row) Source and isolation of stem cells/cells, usually autologous. Abbreviation: MSCs, mesenchymal stem cells. (Second row) 3D scaffolds, where oxygen-generating biomaterials may enhance the formation of the microvasculature. (Third row) Growth factors, peptides, or stimulation to enhance cell proliferation and integration to the surrounding tissue. (Fourth row) Constructs can be placed in bioreactors in vitro or inside patients in vivo prior to transplantation [6]. Trends in Biotechnology 2016 34, 1010-1021DOI: (10.1016/j.tibtech.2016.05.012) Copyright © 2016 Elsevier Ltd Terms and Conditions