Pantothenic acid deficiency and toxicity

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Pantothenic acid deficiency and toxicity Domina Petric, MD

Pantothenic acid deficiency November 24, 2018 Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc. 2008.

Introduction Deprivation of pantothenic acid results in metabolic impairments, including reduced lipid synthesis and energy production. Signs and symptoms of pantothenic acid deficiency involve the skin, liver, adrenals and nervous system. November 24, 2018 Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc. 2008.

Introduction Dietary deficiencies of pantothenic acid are rare. Deficiencies are more common in circumstances of inadequate intake of basic foods and vitamins, and are often associated with (and mistakenly diagnosed as) deficiencies of other vitamins. November 24, 2018 Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc. 2008.

General signs Organ system/function Signs Appetite Decreased Growth Vital organs Hepatic steatosis, thymic necrosis, adrenal hypertrophy Dermatologic Dermatitis, achromotrichia, alopecia Muscular Weakness Gastrointestinal Ulcers Nervous Ataxia, paralysis November 24, 2018 Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc. 2008.

Pantothenic acid antagonists Ѡ-methylpantothenic acid desthio-CoA hopantenate November 24, 2018 Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc. 2008.

Deficiency signs Neurologic signs: paresthesia in the toes and sole of the feet. Depression, fatigue and insomnia. Vomiting, muscular weakness and gastrointestinal disturbances. Changes in glucose tolerance, increased sensitivity to insulin and decreased antibody production. November 24, 2018 Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc. 2008.

Excretion Urinary pantothenic acid excretion has been found to be low for pregnant women, adolescents and the elderly compared with the general population. November 24, 2018 Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc. 2008.

Pantothenic acid toxicity II. November 24, 2018 Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc. 2008.

Pantothenic acid toxicity The toxicity of pantothenic acid is negligible. Massive doses (10 g/day) have not produced reactions more severe than mild intestinal distress and diarrhea. November 24, 2018 Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc. 2008.

Literature Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc. 2008. November 24, 2018