Variation in circulating antimüllerian hormone precursor during the periovulatory and acute postovulatory phases of the human ovarian cycle Michael W.

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Presentation transcript:

Variation in circulating antimüllerian hormone precursor during the periovulatory and acute postovulatory phases of the human ovarian cycle Michael W. Pankhurst, Ph.D., Yih Harng Chong, M.B.Ch.B., Ph.D. Fertility and Sterility Volume 106, Issue 5, Pages 1238-1243.e2 (October 2016) DOI: 10.1016/j.fertnstert.2016.06.010 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Representative serum antimüllerian hormone prohormone index (API) profiles during the ovarian cycle for four women. (A–C) Women with normal ovarian cycles according to levels of luteinizing hormone (LH), follicles-stimulating hormone (FSH), estradiol, progesterone, and inhibin B. (D) The API profile from a woman who was excluded from the study, who had no apparent LH surge in the expected periovulatory period (menstrual cycle days 11–17). Data are shown for total AMH (green, closed circles), AMHN,C (blue, closed diamonds), proAMH (red, closed squares), API (black, closed circles), LH (grey, open circles), and FSH (grey, closed diamonds). Fertility and Sterility 2016 106, 1238-1243.e2DOI: (10.1016/j.fertnstert.2016.06.010) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Changes in serum antimüllerian hormone prohormone index (API) during the ovarian cycle for the cohort. Data were analyzed by repeated measures analysis of variance; time points that share letters were not statistically significantly different at the P=.05 level. Fol. = follicular; Lut. = luteal. Error bars: standard error of the mean; n = 11. Fertility and Sterility 2016 106, 1238-1243.e2DOI: (10.1016/j.fertnstert.2016.06.010) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Ovarian cycle characteristics of the different antimüllerian hormone (AMH) forms in serum. (A) Total AMH (green, closed circles), AMHN,C (blue, closed diamonds), and proAMH (red, closed squares) concentrations during the ovarian cycle. (B) Estradiol (cyan, open squares) and progesterone (magenta, closed diamonds, dashed line) levels plotted on the same axis. Error bars: standard error of the mean; n for each group in A and B = 11. Fertility and Sterility 2016 106, 1238-1243.e2DOI: (10.1016/j.fertnstert.2016.06.010) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Total antimüllerian hormone (AMH) concentrations of antimüllerian hormone prohormone index (API) fraction from all participants. Each symbol represents AMH samples from a single participant, with common symbols representing all samples from the participant's longitudinal series; n = 121 from 12 women. Fertility and Sterility 2016 106, 1238-1243.e2DOI: (10.1016/j.fertnstert.2016.06.010) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Individual hormone profiles for antimüllerian hormone prohormone index (API), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) for the study participants not included in Figure 1. Profiles are from women with normal ovarian cycles according to levels of LH, FSH, estradiol, progesterone, and inhibin B. Each panel (A–H) represents data from an individual participant. Data are shown for total AMH (green, closed circles), AMHN,C (blue, closed diamonds), proAMH (red, closed squares), API (black, closed circles), LH (grey, open circles), and FSH (grey, closed diamonds). Fertility and Sterility 2016 106, 1238-1243.e2DOI: (10.1016/j.fertnstert.2016.06.010) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Individual hormone profiles for antimüllerian hormone prohormone index (API), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) for the study participants not included in Figure 1. Profiles are from women with normal ovarian cycles according to levels of LH, FSH, estradiol, progesterone, and inhibin B. Each panel (A–H) represents data from an individual participant. Data are shown for total AMH (green, closed circles), AMHN,C (blue, closed diamonds), proAMH (red, closed squares), API (black, closed circles), LH (grey, open circles), and FSH (grey, closed diamonds). Fertility and Sterility 2016 106, 1238-1243.e2DOI: (10.1016/j.fertnstert.2016.06.010) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions