Figure 1 Monogenic forms of diabetes mellitus

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Genetics of diabetes Linkages

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Figure 1 Monogenic forms of diabetes mellitus Figure 1 | Monogenic forms of diabetes mellitus. Shown are genes implicated in a restricted set of monogenic diabetes mellitus subtypes (discussed in the article). Each class of disorder is shown as a box in the central column: neonatal diabetes mellitus (NDM, red); maturity-onset diabetes of the young (MODY, blue); and mitochondrial diabetes mellitus (grey), while syndromic forms are divided based on closer similarity to NDM (pink) or MODY (light blue). The major clinical features of each disorder are described in each box. NDM and MODY with organ dysfunction can have one or more organs affected. Genes are shown as boxes in the outer two columns, with arrows connecting to the disorders for which the genes are implicated. Genes implicated in more than one disorder have arrows to each. CNS, central nervous system. Flannick, J. et al. (2016) Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes Nat. Rev. Endocrinol. doi:10.1038/nrendo.2016.50