Chapter 2: Pharmacological cholesterol-lowering treatment in adults

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Chapter 2: Pharmacological cholesterol-lowering treatment in adults Kidney International Supplements Volume 3, Issue 3, Pages 271-279 (November 2013) DOI: 10.1038/kisup.2013.34 Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 1 Adjusted relation between LDL-C and HR of myocardial infarction by eGFR as a continuous variable. Data are adjusted hazard ratios for MI during a median follow-up period of 48 months. Data are from 836,060 participants in the Alberta Kidney Disease cohort and have been adjusted for age, sex, diabetes, hypertension, Aboriginal status, socioeconomic status, proteinuria categories, statin use, and the Charlson comorbidities (cancer, cerebrovascular disease, congestive heart failure, chronic pulmonary disease, dementia, metastatic solid tumor, MI, liver disease, hemiplegia/paraplegia, peptic ulcer disease, peripheral vascular disease, and rheumatic disease). eGFR, estimated glomerular filtration rate; HR, hazard ratio; LDL-C, low-density lipoprotein cholesterol; MI, myocardial infarction. Reproduced from Tonelli M, Muntner P, Lloyd A, et al. Association between LDL-C and Risk of Myocardial Infarction in CKD. J Am Soc Nephrol 2013; 24: 979–986 with permission from American Society of Nephrology conveyed through Copyright Clearance Center, Inc; accessed http://jasn.asnjournals.org/content/24/6/979.long Kidney International Supplements 2013 3, 271-279DOI: (10.1038/kisup.2013.34) Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 2 Future 10-year coronary risk based on various patient characteristics. Data are unadjusted rates from 1,268,029 participants in the Alberta Kidney Disease cohort. CKD refers to eGFR 15-59.9 ml/min/1.73 m2 or with proteinuria. CABG, coronary artery bypass grafting; CHD, coronary heart disease; CKD, chronic kidney disease; CVA, cerebrovascular accident; DM, diabetes mellitus; MI, myocardial infarction; PTCA, percutaneous transluminal coronary angioplasty; TIA, transient ischemic attack. Kidney International Supplements 2013 3, 271-279DOI: (10.1038/kisup.2013.34) Copyright © 2013 International Society of Nephrology Terms and Conditions