Hematopoietic Cell Transplantation with Cord Blood for Cure of HIV Infections Lawrence D. Petz, Istvan Redei, Yvonne Bryson, Donna Regan, Joanne Kurtzberg,

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Hematopoietic Cell Transplantation with Cord Blood for Cure of HIV Infections Lawrence D. Petz, Istvan Redei, Yvonne Bryson, Donna Regan, Joanne Kurtzberg, Elizabeth Shpall, Jonathan Gutman, Sergio Querol, Pamela Clark, Richard Tonai, Sarah Santos, Aide Bravo, Stephen Spellman, Loren Gragert, John Rossi, Shirley Li, Haitang Li, David Senitzer, John Zaia, Joseph Rosenthal, Stephen Forman, Robert Chow Biology of Blood and Marrow Transplantation Volume 19, Issue 3, Pages 393-397 (March 2013) DOI: 10.1016/j.bbmt.2012.10.017 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 (A) In vitro study of infectivity by HIV-1 of peripheral blood mononuclear cells (PBMCs) in the posttransplantation period from an HIV-uninfected patient who underwent transplantation with a CCR5-Δ32/Δ32 cord blood. The recipient's PBMCs showed no significant infection with either lab strains of HIV-1, BAL (CCR tropic), or NL4–3 (CXCR4) compared with a normal adult control. (B) A comparison of HIV replication in vitro with the laboratory CCR5 strain HIV-1 BAL for cord blood PBMCs from normal CCR5 wild-type, heterozygous, and homozygous units. There was no detectable replication in vitro in the CCR5-Δ32/Δ32 cord cells compared with significant replication in the heterozygote and wild-type cord cells. Biology of Blood and Marrow Transplantation 2013 19, 393-397DOI: (10.1016/j.bbmt.2012.10.017) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions