RAS and ROS—A Story of Pseudomonas Survival

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Presentation transcript:

RAS and ROS—A Story of Pseudomonas Survival Stacey L. Kolar, George Y. Liu Cell Host & Microbe Volume 21, Issue 5, Pages 551-552 (May 2017) DOI: 10.1016/j.chom.2017.04.009 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Pseudomonas aeruginosa ExoS Targets Ras to Inhibit NADPH-Oxidase Complex Assembly P. aeruginosa uses a type three secretion syringe to inject effector proteins, including ExoS, to manipulate host cells. ExoS ADP-ribosylates Ras, which physically blocks its interaction with PI3K. This interferes with the activation of NADPH oxidase by Akt and PKC, which inhibits assembly and ultimately ROS production. Cell Host & Microbe 2017 21, 551-552DOI: (10.1016/j.chom.2017.04.009) Copyright © 2017 Elsevier Inc. Terms and Conditions