EPR-based tumor uptake of [68Ga]Ga-1 for effective PET imaging.

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EPR-based tumor uptake of [68Ga]Ga-1 for effective PET imaging. EPR-based tumor uptake of [68Ga]Ga-1 for effective PET imaging. Comparison of the tumor accumulation of the dendrimer nanosystem [68Ga]Ga-1, the small molecular complex [68Ga]Ga-NOTA, and the clinical reference [18F]FDG in ectopic (A) SOJ6- and (B) LIPC-xenografted mice as well as in (C) orthotopic SOJ6-xenograft mice. (Top) Representative examples of [18F]FDG (Left), [68Ga]Ga-NOTA (Middle), and [68Ga]Ga-1 (Right) PET images. The orange arrows indicate tumor positions. (Middle) Quantifications from PET images of tumor uptake, expressed as mean ± SD percentage injected dose per gram (n = 3; *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, and ****P ≤ 0.0001, Kruskal–Wallis test). (Bottom) Quantifications from PET images of tumor-to-background ratios (right forelimb biceps muscle taken as background reference), expressed as mean ± SD percentage (n = 3; *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, Kruskal–Wallis test). (D) Correlation between [68Ga]Ga-1 PET signal in tumors and tumor blood flow assessed by 3D-Doppler (percentage) in orthotopic SOJ6-xenografted mice (n = 3; two time points; Pearson correlation R2 = 0.751; *P = 0.0255). Philippe Garrigue et al. PNAS 2018;115:45:11454-11459 ©2018 by National Academy of Sciences