Volume 3, Issue 3, Pages (May 2017)

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Volume 3, Issue 3, Pages 222-224 (May 2017) Metastatic basal cell carcinoma with loss of p63 and mismatch repair proteins Nathan M. Johnson, MS, Alex C. Holliday, MD, David T. Luyimbazi, MD, Mariana A. Phillips, MD, George R. Collins, DO, Douglas J. Grider, MD JAAD Case Reports Volume 3, Issue 3, Pages 222-224 (May 2017) DOI: 10.1016/j.jdcr.2017.02.018 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Gross image of the primary tumor in a patient with basal cell carcinoma in his left upper extremity. We appreciate John Trenton Gay, DO, for providing this clinical photo. JAAD Case Reports 2017 3, 222-224DOI: (10.1016/j.jdcr.2017.02.018) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Histologic examination of a punch biopsy from a patient with basal cell carcinoma. The initial punch biopsy and amputation resection of the primary tumor showed basaloid tumor cell nests with peripheral palisading and tumor stromal clefting with an infiltrative growth pattern and foci of a poorly differentiated tumor in deeper aspects. (Hematoxylin-eosin stain; original magnification: ×20.) JAAD Case Reports 2017 3, 222-224DOI: (10.1016/j.jdcr.2017.02.018) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 p63-positive primary basal cell carcinoma. (p63 staining; original magnification: ×200.) JAAD Case Reports 2017 3, 222-224DOI: (10.1016/j.jdcr.2017.02.018) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 p63-negative metastatic basal cell carcinoma in the pretracheal lymph node. (p63 staining; original magnification: ×400.) JAAD Case Reports 2017 3, 222-224DOI: (10.1016/j.jdcr.2017.02.018) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions