The Impact of Freeze-Thaw Cycles on Epinephrine

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Presentation transcript:

The Impact of Freeze-Thaw Cycles on Epinephrine Heather Beasley, BS, Pearlly Ng, MD, Albert Wheeler, MD, William R. Smith, MD, Scott E. McIntosh, MD, MPH Wilderness & Environmental Medicine Volume 26, Issue 4, Pages 514-519 (December 2015) DOI: 10.1016/j.wem.2015.04.001 Copyright © 2015 Wilderness Medical Society Terms and Conditions

Figure 1 EpiPen autoinjector that has been disassembled to show internal ampule. Solution has been removed. Wilderness & Environmental Medicine 2015 26, 514-519DOI: (10.1016/j.wem.2015.04.001) Copyright © 2015 Wilderness Medical Society Terms and Conditions

Figure 2 Degradation reactions of l-epinephrine. Adrenochrome creates a colored precipitate within epinephrine solutions. Discoloration of EpiPens indicates degradation has occurred and the autoinjector should be discarded. Wilderness & Environmental Medicine 2015 26, 514-519DOI: (10.1016/j.wem.2015.04.001) Copyright © 2015 Wilderness Medical Society Terms and Conditions