Treatment responsiveness of phenotypes of symptomatic airways obstruction in adults James Fingleton, PhD, Justin Travers, MBChB, Mathew Williams, Dip.

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Presentation transcript:

Treatment responsiveness of phenotypes of symptomatic airways obstruction in adults James Fingleton, PhD, Justin Travers, MBChB, Mathew Williams, Dip Ex Sci, Thomas Charles, DipSM, Darren Bowles, MBChB, Rianne Strik, BSc, Philippa Shirtcliffe, MBChB, Mark Weatherall, MBChB, Richard Beasley, DSc James Fingleton, Justin Travers, Mark Weatherall, Richard Beasley, Mathew Williams, Philippa Shirtcliffe, Thomas Charles, Darren Bowles, Irene Braithwaite, Rianne Strik, Natalie Dooney, Tanya Baker, Mitesh Patel, Mark Holliday, Maureen Stretch, Alison Pritchard, Denise Fabian, Claire Munro, Alexander Hosking, Alex Brinded, Gordon Purdie James Fingleton, PhD, Justin Travers, MBChB, Mathew Williams, Dip Ex Sci, Thomas Charles, DipSM, Darren Bowles, MBChB, Rianne Strik, BSc, Philippa Shirtcliffe, MBChB, Mark Weatherall, MBChB, Richard Beasley, DSc James Fingleton, Justin Travers, Mark Weatherall, Richard Beasley, Mathew Williams, Philippa Shirtcliffe, Thomas Charles, Darren Bowles, Irene Braithwaite, Rianne Strik, Natalie Dooney, Tanya Baker, Mitesh Patel, Mark Holliday, Maureen Stretch, Alison Pritchard, Denise Fabian, Claire Munro, Alexander Hosking, Alex Brinded, Gordon Purdie Journal of Allergy and Clinical Immunology Volume 136, Issue 3, Pages 601-609 (September 2015) DOI: 10.1016/j.jaci.2015.01.013 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Study flow diagram. Twenty-nine of the 418 participants who completed phase 2 were missing data for 1 or more of the 13 cluster analysis variables and therefore could not be included in the cluster analysis. Journal of Allergy and Clinical Immunology 2015 136, 601-609DOI: (10.1016/j.jaci.2015.01.013) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Three-dimensional scatter plot of clusters: yellow, asthma-COPD overlap group; blue, moderate-to-severe, childhood-onset atopic asthma; green, mild, childhood-onset, atopic asthma; red, obese with comorbidities; white, mild, reference group. The figure shows a 3-dimensional model in which each of the 389 subjects in the cluster analysis is represented by a sphere. The color of the sphere indicates the assigned phenotype. The axes are those used in the allocation rule: FEV1 percent predicted, age of onset, and body mass index. Examination of the model in different planes highlights that the obese-comorbid group separates out on body mass index, whereas the remaining 4 clusters are differentiated based on age of onset and disease severity. Journal of Allergy and Clinical Immunology 2015 136, 601-609DOI: (10.1016/j.jaci.2015.01.013) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions