Volume 132, Issue 3, Pages (March 2007)

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Volume 132, Issue 3, Pages 1180-1183 (March 2007) Hepatitis B Virus X Protein and Pin1 in Liver Cancer: “Les Liaisons Dangereuses” Matias A. Avila, Kun P. Lu Gastroenterology Volume 132, Issue 3, Pages 1180-1183 (March 2007) DOI: 10.1053/j.gastro.2007.01.061 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 The interaction and presumably isomerization (inset) of Ser-phosphorylated HBV X-protein (HBx) by the prolyl isomerase Pin1 increases the half-life of the viral protein. This results in the synergistic increase in the expression of HBx-target genes involved in HCC cell growth, survival, and tumorigenic potential. Gastroenterology 2007 132, 1180-1183DOI: (10.1053/j.gastro.2007.01.061) Copyright © 2007 AGA Institute Terms and Conditions