Current Results and Future Research Priorities in Late Effects after Hematopoietic Stem Cell Transplantation for Children with Sickle Cell Disease and.

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Presentation transcript:

Current Results and Future Research Priorities in Late Effects after Hematopoietic Stem Cell Transplantation for Children with Sickle Cell Disease and Thalassemia: A Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric Hematopoietic Stem Cell Transplantation Shalini Shenoy, Emanuele Angelucci, Staci D. Arnold, K. Scott Baker, Monica Bhatia, Dorine Bresters, Andrew C. Dietz, Josu De La Fuente, Christine Duncan, Javid Gaziev, Allison A. King, Michael A. Pulsipher, Angela R. Smith, Mark C. Walters Biology of Blood and Marrow Transplantation Volume 23, Issue 4, Pages 552-561 (April 2017) DOI: 10.1016/j.bbmt.2017.01.009 Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Mechanism of iron-related tissue injury in thalassemia patients. At transferrin saturation levels > 60% to 70%, levels of nontransferrin-bound serum iron (NTBI) and labile plasma iron (LPI) increase, resulting in iron-related damage to the liver, heart, bone marrow, and bones in situations of chronic iron overload after chronic transfusion therapy for thalassemia. (Modified from Angelucci and Pilo [60]). Biology of Blood and Marrow Transplantation 2017 23, 552-561DOI: (10.1016/j.bbmt.2017.01.009) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions