Extension Attachment Contraction Release Recycling C o n t r a c i x e

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Presentation transcript:

Extension Attachment Contraction Release Recycling C o n t r a c i x e F Attachment Contraction Release Recycling

Attachment and Contraction

FN Bead Binding Movement and Release Displacement

How does a cell treat the ECM?

Unstressed Attachments Choquet et al., Cell. 88:39 (1997)

Force Causes Reinforcement

Force Causes GFP-Paxillin Accumulation in RPTPa+/+ with FN Without Force FN Bead Con A Bead

RPTPa Deletion Blocks But Transfection Restores Binding -/- Cells with Force -/- Transfected wtRPTPa

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Horwitz, Scientific American

Summary of Course Lectures 1-Intro 2-Diffusion 3-Diff.Transport 4-Nuclear Organization 5.Nuc.Binding 6 DNA Replication 7 RNA Transcription 8-RNA FactorBind.doc 9-Fluid Bilayer 10-Guoy-Chapman 11-Membrane Potential 12 Protein Translation 13-Cytoskeleton 14-Self-Assembly 15-16Molec.Mech.Q.doc 16-Molecular Motors 17-Mechanics 18-Motor Kinetics 19 Protein Translocation 20 Fission and Fusion 21 Proteol-Degrad 22 Signal Integration 23 Cell Migration 24 Cell Motility ()