SURVEY OF BIOCHEMISTRY Fatty Acid Oxidation

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Presentation transcript:

SURVEY OF BIOCHEMISTRY Fatty Acid Oxidation

Overview of Lipid Metabolism

Triglyceride Breakdown Triglycerides break down into 3 fatty acids and one molecule of glycerol.

Activation of Fatty Acids Acyl-CoA Synthetase Step 1

Activation of Fatty Acids Acyl-CoA Synthetase Step 2

Carnitine as a Carrier

Carnitine as a Carrier

Fatty Acid Oxidation Saturated Fatty Acyl-CoA

Fatty Acid Oxidation Step 2

Fatty Acid Oxidation Step 3

Fatty Acid Oxidation Step 4

Examples of Unsaturated Fatty Acids

Oxidation of Unsaturated Fatty Acids

Oxidation of Unsaturated Fatty Acids

Oxidation of Unsaturated Fatty Acids

Oxidation of Unsaturated Fatty Acids Moves the double bond!

Another Problem in Oxidizing Unsaturated Fatty Acids Poor substrate for enoyl-CoA hydratase

Alternative Pathway for Unsaturated Fatty Acids Study Figure 20-12 and Figure 20-15

Odd-Chain Fatty Acids