Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma Virginia Norris, MRCP, Lee Choong, BSc, Duyen Tran,

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Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma Virginia Norris, MRCP, Lee Choong, BSc, Duyen Tran, BSc, Zoe Corden, BSc, Malcolm Boyce, FRCP, Hasan Arshad, MD, Stephen Holgate, MD, Brian O'Connor, MD, Sylvaine Millet, BSc, Barry Miller, MS, Shashank Rohatagi, PhD, Stephane Kirkesseli, MD Journal of Allergy and Clinical Immunology Volume 116, Issue 4, Pages 761-767 (October 2005) DOI: 10.1016/j.jaci.2005.04.045 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Pharmacokinetics of IVL745 (mean [SD]) on day 8, with IC50 VLA-fibronectin and IC50 VLA–VCAM-1 values shown. Journal of Allergy and Clinical Immunology 2005 116, 761-767DOI: (10.1016/j.jaci.2005.04.045) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Mean change (percentage) in FEV1 from prechallenge value in the 9 hours after allergen inhalation on day 8 for placebo and IVL745. Journal of Allergy and Clinical Immunology 2005 116, 761-767DOI: (10.1016/j.jaci.2005.04.045) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Percentage of eosinophils and neutrophils in sputum on day 7 (error bars indicate SEM). Journal of Allergy and Clinical Immunology 2005 116, 761-767DOI: (10.1016/j.jaci.2005.04.045) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions