International Journal of Cardiology

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International Journal of Cardiology Left ventricular myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis Yolanda Vives-Gilabert, Jorge Sanz-Sánchez, Pilar Molina, Antonio Cebrián, Begoña Igual, Pilar Calvillo-Batllés, Diana Domingo, José Millet, Luis Martínez-Dolz, Francisco Castells, Esther Zorio International Journal of Cardiology DOI: 10.1016/j.ijcard.2018.09.024 Copyright © 2018 The Authors Terms and Conditions

International Journal of Cardiology DOI: (10. 1016/j. ijcard. 2018. 09 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Global and regional strain analyses. Example of the time-to-peak and peak radial strain of the 16 American Heart Association (AHA) segments (A). Quantitative regional analysis of myocardial dysfunction in patients when compared with controls. The AHA segments with significant wall motion abnormalities are represented in grey since they exhibited delayed time-to-peak (B) (B) and/or decreased strain values (not available for longitudinal analysis). Numbers refer to AHA classification. International Journal of Cardiology DOI: (10.1016/j.ijcard.2018.09.024) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 Receiver-operating characteristic curves. Receiver-operating characteristic curves assessing the discriminative accuracy of volume (A) and strain (B, C) related parameters with statistically significant differences between patients and controls. Volume related parameters: LVEF, LVEDVi and LVESVi. Strain related parameters: radial, circumferential and longitudinal peak strain values and radial and circumferential dyssynchronies. Cut-off values and sensitivities for 100% specificity (D). International Journal of Cardiology DOI: (10.1016/j.ijcard.2018.09.024) Copyright © 2018 The Authors Terms and Conditions

Fig. 3 Delayed apical contraction. CMR sequence in a patient with delayed apical contraction from telediastole (0 ms) and thereafter. Basal (A) and apical (B) segments are shown. International Journal of Cardiology DOI: (10.1016/j.ijcard.2018.09.024) Copyright © 2018 The Authors Terms and Conditions

Online Fig. 1 Group differences attending to volume-related variables (LVEF, LVEDVi and LVESVi) (first row), radial, circumferential and longitudinal strain (second row) and radial, circumferential and longitudinal dyssychronies (third row). International Journal of Cardiology DOI: (10.1016/j.ijcard.2018.09.024) Copyright © 2018 The Authors Terms and Conditions