Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21:

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Presentation transcript:

Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study Aida Semic-Jusufagic, MD, Danielle Belgrave, PhD, Prof Andrew Pickles, PhD, Aurica G Telcian, MD, Eteri Bakhsoliani, MSc, Annemarie Sykes, MD, Prof Angela Simpson, MD, Prof Sebastian L Johnston, MD, Prof Adnan Custovic, MD The Lancet Respiratory Medicine Volume 2, Issue 8, Pages 621-630 (August 2014) DOI: 10.1016/S2213-2600(14)70096-7 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Study profile PCT=primary care trust. GP=general practitioner. PBMC=peripheral blood mononuclear cell. The Lancet Respiratory Medicine 2014 2, 621-630DOI: (10.1016/S2213-2600(14)70096-7) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Analysis of immune response to viral stimuli Interleukin 1β, interleukin 6, interferon γ, interferon α, TNFα, and IP10 protein concentrations in PBMC supernatants after stimulation with RV1B, RSV, and RV16 (all multiplicity of infection of 1). RV=rhinovirus. RSV=respiratory syncytial virus. TNF=tumour necrosis factor. IP10=interferon-γ-induced protein-10. PBMC=peripheral blood mononuclear cell. The Lancet Respiratory Medicine 2014 2, 621-630DOI: (10.1016/S2213-2600(14)70096-7) Copyright © 2014 Elsevier Ltd Terms and Conditions