Pille Link, Prof. Dr. M. Wink University of Heidelberg

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Effects of liquorice on beta-amyloid aggregation and toxicity in Caenorhabditis elegans Pille Link, Prof. Dr. M. Wink University of Heidelberg Institute for Pharmacy and Molecular Biotechnology Conflict of interest: nothing to declare

Glycyrrhiza glabra Used to treat ulcers gastritis cough longing for sweets

Alzheimer‘s disease neurofibrillary tangles G. glabra? oxidative stress inflammation neuronal cell death loss of memory neurofibrillary tangles antioxidant anti inflammatory neuroprotective memory-enhancing http://www.alz.org/braintour/images/ plaques_tangles.jpg G. glabra? amyloid-β plaques Aβ plaques Asl MN & Hosseinzadeh H (2008). Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds. Phytotherapy Research 22: 709-724.

Caenorhabditis elegans: a model for Alzheimer’s disease CL2006 Aβ42 expression in muscle cells number of plaques CL4176 temperature inducible Aβ42 expression in muscle cells progressive paralysis Aβ42 toxicity Link CD (2006). C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Exp Gerontol 41: 1007-1013.

Does G. glabra have an effect on Aβ aggregation?

CL2006: thioflavin S staining

Glycyrrhiza glabra isoliquiritigenin (ILG) glycyrrhetinic acid (GRA) G. glabra G. glabra isoliquiritigenin (ILG) glycyrrhetinic acid (GRA) glycyrrhizic acid (GA) * p < 0.01 concentration: 100 µg/ml

Can G. glabra reduce Aβ-induced toxicity?

Paralysis assay in CL4176 temperature inducible Aβ expression paralysis due to Aβ toxicity

Activity against Aβ-toxicity

Conclusions & outlook extract & pure compounds from G. glabra can: decrease the number of Aβ plaques counteract Aβ toxicity most active compound: isoliquiritigenin further work: test more compuonds clarify the mode of action

Thank you for your attention! IPMB University of Heidelberg Thank you for your attention!