Daniel Saal, Yan Dong, Antonello Bonci, Robert C Malenka Neuron

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Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons Daniel Saal, Yan Dong, Antonello Bonci, Robert C Malenka Neuron Volume 37, Issue 4, Pages 577-582 (February 2003) DOI: 10.1016/S0896-6273(03)00021-7

Figure 1 Psychostimulant Drugs Enhance the AMPA/NMDA EPSC Ratio at Excitatory Synapses on Midbrain DA Cells (A) Example of Ih currents used to identify midbrain DA cells (calibration bars: 20 pA/50 ms). (B) Top traces show example from a control cell of how AMPA/NMDA ratios were obtained. EPSCs were recorded at +40 mV (Dual trace), and then D-APV (50 μM) was applied to obtain the AMPA EPSC. The NMDA EPSC was obtained by digital subtraction of the AMPA EPSC from the dual EPSC. Bottom traces show examples of AMPA and NMDA EPSCs obtained from cocaine- and amphetamine-treated animals (calibration bars: 20 pA/15 ms). (C) Summary of AMPA/NMDA ratios obtained from animals administered saline, cocaine, or amphetamine (asterisk indicates p < 0.02). In this and all subsequent figures, numbers within the bars indicate the number of cells examined. Neuron 2003 37, 577-582DOI: (10.1016/S0896-6273(03)00021-7)

Figure 2 Commonly Abused Drugs Other than Psychostimulants also Increase the AMPA/NMDA Ratio (A) Examples of AMPA and NMDA EPSCs obtained from animals given the indicated substance (calibration bars: 20 pA/15 ms). (B) Summary of AMPA/NMDA ratios obtained from animals administered saline, morphine, nicotine, or ethanol (asterisk indicates p < 0.03). Neuron 2003 37, 577-582DOI: (10.1016/S0896-6273(03)00021-7)

Figure 3 Commonly Used Psychoactive but Nonaddictive Drugs Do Not Affect the AMPA/NMDA Ratio (A) Examples of AMPA and NMDA EPSCs obtained from animals given the indicated substance (calibration bars: 20 pA/15 ms). (B) Summary of AMPA/NMDA ratios obtained from animals administered saline, fluoxetine, or carbamazepine. Neuron 2003 37, 577-582DOI: (10.1016/S0896-6273(03)00021-7)

Figure 4 Acute Stress Increases the AMPA/NMDA Ratio (A) Examples of AMPA and NMDA EPSCs obtained from a control animal and animals experiencing stress plus the indicated substance (calibration bars: 20 pA/15 ms). (B) Summary of AMPA/NMDA ratios obtained from animals administered saline or experiencing stress along with administration of saline, the NMDA receptor antagonist MK801, or the glucocorticoid receptor antagonist RU486 (asterisk indicates p < 0.01). (C) Summary of AMPA/NMDA ratios obtained from animals administered saline, cocaine, or cocaine plus RU486 (asterisk indicates p < 0.05). Neuron 2003 37, 577-582DOI: (10.1016/S0896-6273(03)00021-7)