Individualized Medicine in Gastroenterology and Hepatology Michael C. Stephens, MD, Lisa A. Boardman, MD, Konstantinos N. Lazaridis, MD  Mayo Clinic Proceedings  Volume 92, Issue 5, Pages 810-825 (May 2017) DOI: 10.1016/j.mayocp.2017.03.002 Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure Several specific mechanisms are likely involved in the development of very early onset inflammatory bowel disease (VEOIBD). These include defects of epithelial barrier in the intestine, defects of phagocytosis, defects of T cells and/or B cells, dysregulation of the immune system, defects in genes of rare monogenic disorders and defects in genes of other hyper or autoimmune diseases. Mayo Clinic Proceedings 2017 92, 810-825DOI: (10.1016/j.mayocp.2017.03.002) Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions