Pazopanib, a Receptor Tyrosine Kinase Inhibitor, Suppresses Tumor Growth through Angiogenesis in Dedifferentiated Liposarcoma Xenograft Models  Haifu Li, Agnieszka Wozniak, Raf Sciot, Jasmien Cornillie, Jasmien Wellens, Thomas Van Looy, Ulla Vanleeuw, Marguerite Stas, Daphne Hompes, Maria Debiec-Rychter, Patrick Schöffski  Translational Oncology  Volume 7, Issue 6, Pages 665-671 (December 2014) DOI: 10.1016/j.tranon.2014.09.007 Copyright © 2014 Neoplasia Press, Inc. Terms and Conditions

Figure 1 Representative images of H&E staining, MDM2 immunostaining, and FISH in UZLX-STS3 (p.7) and UZLX-STS5 (p.6) tumors, including H&E-stained images from the original patient samples. On FISH images, green signals identify chromosome 12 centromere, while the red cluster of signals (arrow) represents the amplified MDM2. Translational Oncology 2014 7, 665-671DOI: (10.1016/j.tranon.2014.09.007) Copyright © 2014 Neoplasia Press, Inc. Terms and Conditions

Figure 2 Tumor volume evaluation in SW872, UZLX-STS3, and UZLX-STS5 models. Tumor volume was measured three times per week and is presented as a relative tumor volume (%) compared to day 0. All data points are shown as mean ± SD of at least six tumors per treatment group. Translational Oncology 2014 7, 665-671DOI: (10.1016/j.tranon.2014.09.007) Copyright © 2014 Neoplasia Press, Inc. Terms and Conditions

Figure 3 Representative images of tumor vascularity using CD34 immunostaining in SW872, UZLX-STS3, and UZLX-STS5 models. Images were captured under 400-fold magnification. Translational Oncology 2014 7, 665-671DOI: (10.1016/j.tranon.2014.09.007) Copyright © 2014 Neoplasia Press, Inc. Terms and Conditions