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Nat. Rev. Urol. doi:10.1038/nrurol.2017.134 Figure 2 Several small atypical glands suspicious for carcinoma on the edge of a needle biopsy core Figure 2 | Several small atypical glands suspicious for carcinoma on the edge of a needle biopsy core. Architecturally, the glands are small with slightly amphophilic cytoplasm, but lack cytological atypia, and some are atrophic (arrows). Also, as the glands are on the edge of the gland, one cannot exclude with certainty that they are not outpouchings off adjacent HGPIN or carcinoma that is not represented on the core. Consequently, the risk of cancer following atypical glands on prostate biopsy is ∼40%, which is twofold higher than that following a benign biopsy. Tosoian, J. J. et al. (2017) Managing high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands on prostate biopsy Nat. Rev. Urol. doi:10.1038/nrurol.2017.134