Interferons Coordinate a Multifaceted Defense Kamilla S. Josefsdottir, Katherine Y. King  Cell Host & Microbe  Volume 17, Issue 1, Pages 6-7 (January 2015) DOI: 10.1016/j.chom.2014.12.007 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Summary of the Process of Intestinal Epithelial Response to Injury as Described by Sun et al. (2015) Type I IFN produced by intestinal epithelial cell infected by virus, or by other stimulus on tissue, in turn stimulates macrophage to produce Apol9a. Apol9a is released from macrophage and may be directly taken up by intestinal epithelial progenitor or cause Apol9a production by the progenitor cell by other means. Downstream activation of the ERK pathway occurs, leading to increased proliferation of the intestinal epithelial progenitor cells, allowing rapid regeneration of the intestinal epithelium in response to injury. Cell Host & Microbe 2015 17, 6-7DOI: (10.1016/j.chom.2014.12.007) Copyright © 2015 Elsevier Inc. Terms and Conditions