Simplistic Inflammatory and Non-Inflammatory Effects of Insulin Resistance on B-Cell Function IAPP boosts islet macrophage IL-1 in type 2 diabetes : Nature.

Slides:



Advertisements
Similar presentations
Course: Immunopathology and Immunotherapeutics
Advertisements

Pathophysiology of Type 1 Diabetes
Who gets the autoimmune disease Type 1 diabetes, and why? 35 years of Type 1 diabetes immunology research – an autoimmune disease model emerges How genes.
Classification & Risk Factors for Diabetes Mellitus
18-1 Important terms: Hypersensitivity – immune responses that causes tissue damage Autoimmune disease – immune responses to self-antigens Immunodeficiency.
Pathophysiology of Type 1 Diabetes 1. Type 1 Diabetes Mellitus Characterized by absolute insulin deficiency Pathophysiology and etiology –Result of pancreatic.
Diabetes mellitus. Normal endocrine pancreas 1 million microscopic clusters of cells 1 million microscopic clusters of cells Β,α,δ,PP cells Β,α,δ,PP cells.
IR and Hyperinsulinemia Insulin Resistance: A Survival Mechanism, Gone Awry Stan Schwartz MD,FACP Affiliate, Main Line Health System Emeritus, Clinical.
Type 1 Diabetes Treatment Options Stanley Schwartz Mark Stolar Emeritus, Univ of Pa Part 5.
Plasminogen-Activating Inhibitor-1 (PAI-1) High PAI-1 associated with: Obesity (especially visceral), possible fatty liver. 2,3,4 Inflammation and oxidative.
Diagnosing Diabetes In Adults– Type 1, LADA, or Type 2? Stanley Schwartz MD, FACE, FACP Affiliate Main Line Health Emeritus, Clinical Assoc. Prof. of Medicine.
IR and Hyperinsulinemia Insulin Resistance: A Survival Mechanism, Gone Awry Stan Schwartz MD,FACP Affiliate, Main Line Health System Emeritus, Clinical.
IR and Hyperinsulinemia Insulin Resistance: A Survival Mechanism, Gone Awry Stan Schwartz MD,FACP Affiliate, Main Line Health System Emeritus, Clinical.
Diagnosing Diabetes In Adults– Type 1, LADA, or Type 2? Stanley Schwartz MD, FACE, FACP Affiliate Main Line Health Emeritus, Clinical Assoc. Prof. of Medicine.
IR and Hyperinsulinemia Insulin Resistance: A Survival Mechanism, Gone Awry Stan Schwartz MD,FACP Affiliate, Main Line Health System Emeritus, Clinical.
Diabetes Mellitus 101 for Cardiologists (and Alike): 2015 Stan Schwartz MD,FACP Affiliate, Main Line Health System Emeritus, Clinical Associate Professor.
Diabetes Mellitus 101 for Cardiologists (and Alike): 2015 Stan Schwartz MD,FACP Affiliate, Main Line Health System Emeritus, Clinical Associate Professor.
IR and Hyperinsulinemia Insulin Resistance: A Survival Mechanism, Gone Awry Stan Schwartz MD,FACP Affiliate, Main Line Health System Emeritus, Clinical.
Chapter 15.  Immunological tolerance is defined as unresponsiveness to an antigen that is induced by previous exposure to that antigen  Antigens that.
Dr Zaranyika MBChB(Hons) UZ, MPH, FCP SA Department of Medicine UZ-CHS.
Dr. Aneela javed IMMUNOPATHOLOGY AND IMMUNOTHERAPY (BPH-375) Credit Hrs 3(2-1)
Pathogenesis and biological interventions in T1DM- LIKE autoimmune diabetes- Insulitis The class I MHC molecules are hyperexpressed on the β-cell surface.
A Process Of Precision Medicine- Matching Right Drug to Right Patient.
Efficacy of Immunotherapy in T1DM: Some Can Delay Decline in C-peptide
CV Risk of SU and Insulin
The β-Cell Centric Classification of DM
Once Upon a Time, Insulin Resistance was Adaptive… but Not Today
A Process Of Precision Medicine- Matching Right Drug to Right Patient
Medical Immunology.
Beta-Cell Classification of Diabetes and the Egregious Eleven: Logic for Newer Algorithms/ Processes of Care The Role of Newer Anti-Diabetes Medications.
Pathophysiology of Type 1 Diabetes
A Clinical-Translator’s Point-of-View:
Unified Theory of Diabetes and All Its Complications
IMMUNITY II.
Proposed pathogenesis of inflammatory bowel disease and target sites for pharmacological intervention. Shown are the interactions among bacterial antigens.
Treatment of Type 2 Diabetes: Pathophysiology Conclude: do so without Hypoglycemia or Visceral Fat Weight Gain 1.
Pushback What about ‘pure’ Insulin Resistance Syndromes?
Autoimmune hepatitis – Update 2015
Figure 5 Dendritic cells in liver inflammation
NCOA5, IL-6, Type 2 Diabetes, and HCC: The Deadly Quartet
Inflammation/Immune Issues
Figure 1 Contribution of the gut microbiota
How to Approach a Patient With Nonalcoholic Fatty Liver Disease
Nat. Rev. Endocrinol. doi: /nrendo
The β-Cell Centric Classification of DM
Cytotoxic Hypersensitivity (Type II)
Fat Chance: Not Much against NKT Cells
David R. Meldrum, M. D. , Marge A. Morris, M. Ed. , R. D. , C. D. E
T –HELPER CELL AMMAR HADI
1.
Nat. Rev. Endocrinol. doi: /nrendo
Adrian Kee Keong Teo, Amy J. Wagers, Rohit N. Kulkarni  Cell Metabolism 
NCOA5, IL-6, Type 2 Diabetes, and HCC: The Deadly Quartet
Nat. Rev. Nephrol. doi: /nrneph
Pg and Ec LPS induced levels of soluble mediators from in cultures of individuals with and without T2D with periodontitis. Pg and Ec LPS induced levels.
Statins, Obesity, and Hyperlipidemia
The Autoimmune insulin-dependent Diabetes mellitus:
Jonathan H. Esensten, MD, PhD, Yannick D. Muller, MD, PhD, Jeffrey A
Chengcheng Jin, Jorge Henao-Mejia, Richard A. Flavell  Cell Metabolism 
An Integrated View of Immunometabolism
What is type 1 diabetes? Medicine
David R. Meldrum, M. D. , Marge A. Morris, M. Ed. , R. D. , C. D. E
Translating Inflammatory Bowel Disease Research into Clinical Medicine
Subhra K. Biswas, Raffaella Bonecchi  Cell Metabolism 
Once Upon a Time, Insulin Resistance was Adaptive… but Not Today
Mechanisms of B-cell involvement in β-cell autoimmunity
Curtis 2002/p47/c1/para5, p48/Table2
Sander Lefere, Frank Tacke  JHEP Reports 
Eosinophilic gastrointestinal disorders (EGID)
How to Approach a Patient With Nonalcoholic Fatty Liver Disease
Presentation transcript:

Simplistic Inflammatory and Non-Inflammatory Effects of Insulin Resistance on B-Cell Function IAPP boosts islet macrophage IL-1 in type 2 diabetes : Nature ...www.nature.com

Inflammation in IR

Pathogenesis and biological interventions in T1DM- LIKE autoimmune diabetes- Insulitis The class I MHC molecules are hyperexpressed on the β-cell surface in T1D patients making β-cells more susceptible to cytotoxic lymphocyte (CTL)-mediated destruction. Novel diagnostic and therapeutic approaches for autoimmune diabetes — A prime time to treat insulitis as a disease http://dx.doi.org/10.1016/j.clim.2014.11.007 Clinical Immunology, 2014 Juha Grönholm , Michael J. Lenardo

Treatment IR induced Inflammation

Implications for Therapy Treat Central Mechanisms IR Treat Peripheral IR- fat, liver, muscle Treat Inflammation Treat Biome

Metabolic Derangement, and Insulin Resistance Associated with Microbiome Lipopolysaccharides LPS Fasting-induced adipocyte factor Pioglitazone Treats Secondary Adverse Effects of Abnormal Biome

Probiotic, Prebiotic and Antibiotic Treatment of Abnormal Gut Biome

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.