Volume 148, Issue 1, Pages 77-87.e2 (January 2015) Association Between Molecular Subtypes of Colorectal Cancer and Patient Survival  Amanda I. Phipps, Paul J. Limburg, John A. Baron, Andrea N. Burnett-Hartman, Daniel J. Weisenberger, Peter W. Laird, Frank A. Sinicrope, Christophe Rosty, Daniel D. Buchanan, John D. Potter, Polly A. Newcomb  Gastroenterology  Volume 148, Issue 1, Pages 77-87.e2 (January 2015) DOI: 10.1053/j.gastro.2014.09.038 Copyright © 2015 AGA Institute Terms and Conditions

Figure 1 Kaplan-Meier survival curves comparing disease-specific survival in colorectal cancer patients by tumor subtype: type 1 (dashed black), type 2 (dotted black), type 3 (solid gray), type 4 (solid black), type 5 (dashed gray), some other tumor marker combination (dotted gray). Subtypes are defined as follows: type 1 = MSI-high, BRAF-mutated, KRAS-mutation–negative, CIMP+; type 2 = MSS/MSI-low, BRAF-mutated, KRAS-mutation–negative, CIMP+; type 3 = MSS/MSI-low, BRAF-mutation–negative, KRAS-mutated, non-CIMP; type 4 = MSS/MSI-low, BRAF-mutation–negative, KRAS-mutation–negative, non-CIMP; type 5 = MSI-high, BRAF-mutation–negative, KRAS-mutation–negative, non-CIMP. Gastroenterology 2015 148, 77-87.e2DOI: (10.1053/j.gastro.2014.09.038) Copyright © 2015 AGA Institute Terms and Conditions

Figure 2 Kaplan-Meier survival curves comparing overall survival in colorectal cancer patients by tumor subtype: type 1 (dashed black), type 2 (dotted black), type 3 (solid gray), type 4 (solid black), type 5 (dashed gray), some other tumor marker combination (dotted gray). Subtypes are defined as follows: type 1 = MSI-high, BRAF-mutated, KRAS-mutation–negative, CIMP+; type 2 = MSS/MSI-low, BRAF-mutated, KRAS-mutation–negative, CIMP+; type 3 = MSS/MSI-low, BRAF-mutation–negative, KRAS-mutated, non-CIMP; type 4 = MSS/MSI-low, BRAF-mutation–negative, KRAS-mutation–negative, non-CIMP; type 5 = MSI-high, BRAF-mutation–negative, KRAS-mutation–negative, non-CIMP. Gastroenterology 2015 148, 77-87.e2DOI: (10.1053/j.gastro.2014.09.038) Copyright © 2015 AGA Institute Terms and Conditions

Supplementary Figure 1 Distribution of tumor marker combinations and subtype classifications. Gastroenterology 2015 148, 77-87.e2DOI: (10.1053/j.gastro.2014.09.038) Copyright © 2015 AGA Institute Terms and Conditions