PARG: A Macrodomain in Disguise

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PARG: A Macrodomain in Disguise Markus Hassler, Gytis Jankevicius, Andreas G. Ladurner Structure Volume 19, Issue 10, Pages 1351-1353 (October 2011) DOI: 10.1016/j.str.2011.09.007 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 Comparison of T. curvata PARG in Complex with ADP-Ribose with Three Representative Macrodomain Structures Cartoon view of (A) PARG with ADP-ribose (PDB ID 3SIG), (B) macroH2A1.1 with ADP-ribose (PDB ID 3IID), (C) MacroD1 (PDB ID 2X47), and (D) YmdB (PDB ID 1SPV) showing the core α-β-α sandwich fold typical of macrodomains in blue. Extended noncanonical structural features are shown in pale green. ADP-ribose is shown in yellow. The signature GGG-X6-8-QEE loop in PARG and the Gly-rich loops typical in macrodomains are shown in red. The conserved GVFG stretches are shown in orange. Structure 2011 19, 1351-1353DOI: (10.1016/j.str.2011.09.007) Copyright © 2011 Elsevier Ltd Terms and Conditions