Blockade of spinal nerves inhibits expression of neural growth factor in the myocardium at an early stage of acute myocardial infarction in rats W. Yue,

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Blockade of spinal nerves inhibits expression of neural growth factor in the myocardium at an early stage of acute myocardial infarction in rats W. Yue, Z. Guo British Journal of Anaesthesia Volume 109, Issue 3, Pages 345-351 (September 2012) DOI: 10.1093/bja/aes144 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 Identification of the myocardium at risk of ischaemia and changes in ECG during AMI. (a) The red colour indicates the myocardium at risk. (b) ECG before and at 10, 15, 30, 180, and 360 min after CAO, showing the elevation of ST-segment and arrhythmia during AMI. A representative experiment from a single animal. CAO, coronary artery occlusion; AMI, acute myocardial infarction. British Journal of Anaesthesia 2012 109, 345-351DOI: (10.1093/bja/aes144) Copyright © 2012 The Author(s) Terms and Conditions

Fig 2 Changes in arterial pressure and heart rate. (a) Arterial pressure (mm Hg). (b) Heart rate (beats min−1). Arrows indicate the start of epidural anaesthesia (E), the thoracotomy (T), and the CAO (C). British Journal of Anaesthesia 2012 109, 345-351DOI: (10.1093/bja/aes144) Copyright © 2012 The Author(s) Terms and Conditions

Fig 3 The location of NGF immunoreactive cells and fibres in the myocardium. In the myocardium at risk of ischaemia, NGF immunoreactive cells were mainly located in the epicardium (Ep, a–c) and the myocardium (d–f). The NGF immunoreactive fibre-like structures (g–i) were observed in the myocardium. The arrows indicate the origins of the insets in the images (representative experiment from three animals). Bars are 500 µm in (a and d), 200 µm in (b), 100 µm in (h), and 50 µm in (c, e–g, and i). British Journal of Anaesthesia 2012 109, 345-351DOI: (10.1093/bja/aes144) Copyright © 2012 The Author(s) Terms and Conditions

Fig 4 Changes in the NGF protein in the ischaemic myocardium in sham surgery (sham), CAO, and epidural anaesthesia plus CAO (EA) groups at 15, 30, 60, and 360 min after CAO. S1: P=0.027, CAO vs EA; S2: P=0.05, sham vs CAO; S3: P=0.0001, CAO vs EA; S4: P=0.002, sham vs CAO; S5: P=0.0001, CAO vs EA; NS1: P=0.132, sham vs CAO; NS2: P=1.0, sham vs CAO; NS3: P=1.0, CAO vs EA. TP, total protein. British Journal of Anaesthesia 2012 109, 345-351DOI: (10.1093/bja/aes144) Copyright © 2012 The Author(s) Terms and Conditions

Fig 5 Expression of the NGF mRNA in the ischaemic myocardium in sham surgery (sham), CAO, and epidural anaesthesia plus CAO (EA) groups at 15 and 360 min after CAO. S1: P=0.005, sham vs CAO; S2: P=0.048, CAO vs EA; NS1: P=0.799, sham vs CAO; NS2: P=0.323, CAO vs EA. British Journal of Anaesthesia 2012 109, 345-351DOI: (10.1093/bja/aes144) Copyright © 2012 The Author(s) Terms and Conditions