Tolerant beekeepers display venom-specific functional IgG4 antibodies in the absence of specific IgE Eva-Maria Varga, MD, Fahima Kausar, MSc, Werner.

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Presentation transcript:

Tolerant beekeepers display venom-specific functional IgG4 antibodies in the absence of specific IgE Eva-Maria Varga, MD, Fahima Kausar, MSc, Werner Aberer, MD, Maximilian Zach, MD, Ernst Eber, MD, Stephen R. Durham, MD, Mohamed H. Shamji, PhD Journal of Allergy and Clinical Immunology Volume 131, Issue 5, Pages 1419-1421 (May 2013) DOI: 10.1016/j.jaci.2012.08.037 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Serum PLA2-specific IgG4 antibodies. B, Serum PLA2-specific IgE antibodies. C, The level of serum IgE–associated binding activity for allergen-IgE complexes to B cells. Data are given for tolerant beekeepers (BK), bee venom–allergic controls (AC), and nonatopic normal healthy controls (NC). Mann-Whitney test (P < .05 considered significant). PLA2, Phospholipase A2. Journal of Allergy and Clinical Immunology 2013 131, 1419-1421DOI: (10.1016/j.jaci.2012.08.037) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Serum PLA2-specific IgG4 antibodies. B, Serum PLA2-specific IgE antibodies. C, The level of serum IgG–associated inhibitory activity for binding of allergen-IgE complexes to B cells. Data are given for tolerant beekeepers inside (July) and outside (January) the beekeeping season. Wilcoxon matched-pairs signed ranks test (P < .05 considered significant). PLA2, Phospholipase A2. Journal of Allergy and Clinical Immunology 2013 131, 1419-1421DOI: (10.1016/j.jaci.2012.08.037) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions