Volume 92, Issue 1, Pages 2-3 (July 2017) Journal club    Kidney International  Volume 92, Issue 1, Pages 2-3 (July 2017) DOI: 10.1016/j.kint.2017.05.007 Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure 1 Efficacy of combination therapy with 1, 2, 3, and 4 drugs at quarter-dose on blood pressure lowering, compared with placebo. Data for 1 and 2 drugs at quarter-dose are from the systematic review. Data for 4 drugs at quarter-dose are from the trial reported here. No data were available for 3 drugs at quarter-dose. Reprinted from the Lancet, Vol. 389, Chow CK, Thakkar J, Bennett A, et al., Quarter-dose quadruple combination therapy for initial treatment of hypertension: placebo-controlled, crossover, randomised trial and systematic review, pages 1035–1042, Copyright © 2017, with permission from Elsevier. Kidney International 2017 92, 2-3DOI: (10.1016/j.kint.2017.05.007) Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure 2 FOXO-DRI reduced interleukin-6 expression in kidneys from prematurely aged mice. Reprinted from Cell., Baar MP, Brandt RMC, Putavet DA, et al., Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging, 169:132–147.e16, Copyright © 2017, with permission from Elsevier. To optimize viewing of this image, please see the online version of this article at www.kidney-international.org. Kidney International 2017 92, 2-3DOI: (10.1016/j.kint.2017.05.007) Copyright © 2017 International Society of Nephrology Terms and Conditions