Meta-analysis of randomised phase III clinical trials comparing EGFR tyrosine kinase inhibitor (TKI) shows that male patients with non-small cell lung cancer (NSCLC) have a minor benefit from these drugs (A) compared with female patients who have a 10% additional reduction in progression risk (B). Meta-analysis of randomised phase III clinical trials comparing EGFR tyrosine kinase inhibitor (TKI) shows that male patients with non-small cell lung cancer (NSCLC) have a minor benefit from these drugs (A) compared with female patients who have a 10% additional reduction in progression risk (B). Funnel plots for the detection of publication bias in the meta-analysis of men (C) and women (D). Joseph A Pinto et al. ESMO Open 2018;3:e000344 Copyright © European Society for Medical Oncology. All rights reserved.