Breaking Down Resistance

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Presentation transcript:

Breaking Down Resistance Cell Volume 159, Issue 3, (October 2014) DOI: 10.1016/j.cell.2014.10.017 Copyright © 2014 Terms and Conditions

Unexpected signaling crosstalk underlies resistance to targeted therapy (Created by Caitlyn Webster; courtesy of Monique Dail and Kevin Shannon). Cell 2014 159, DOI: (10.1016/j.cell.2014.10.017) Copyright © 2014 Terms and Conditions

The tyrosine kinase inhibitor ponatinib (orange) binds to the ABL1T315I kinase domain (upper) but not ABLE255V/T315I (lower, point mutants in yellow) (Courtesy of Matthew Zabriskie and Nadeem Vellore). Cell 2014 159, DOI: (10.1016/j.cell.2014.10.017) Copyright © 2014 Terms and Conditions